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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MFN2
All Species:
43.64
Human Site:
T680
Identified Species:
87.27
UniProt:
O95140
Number Species:
11
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O95140
NP_001121132.1
757
86402
T680
L
Q
L
V
I
S
Y
T
G
S
N
C
S
H
Q
Chimpanzee
Pan troglodytes
XP_514395
805
91725
T728
L
Q
L
V
I
S
Y
T
G
S
N
C
S
H
Q
Rhesus Macaque
Macaca mulatta
XP_001108853
741
84052
T661
L
K
M
I
V
S
S
T
S
A
N
C
S
H
Q
Dog
Lupus familis
XP_865287
757
86272
T680
L
Q
L
I
I
S
Y
T
G
S
N
C
S
H
Q
Cat
Felis silvestris
Mouse
Mus musculus
Q80U63
757
86169
T680
L
Q
L
I
I
S
Y
T
G
S
N
C
S
H
Q
Rat
Rattus norvegicus
Q8R500
757
86104
T680
L
Q
L
I
I
S
Y
T
G
S
N
C
S
H
Q
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001505565
839
94273
T684
L
Q
M
I
V
S
F
T
S
A
N
C
S
H
Q
Chicken
Gallus gallus
XP_417640
1166
133201
T1089
L
Q
L
I
V
S
Y
T
G
S
N
C
S
H
Q
Frog
Xenopus laevis
NP_001084869
756
86248
T680
L
Q
L
I
V
S
Y
T
G
S
N
C
S
H
Q
Zebra Danio
Brachydanio rerio
NP_001121726
757
85922
T680
L
Q
L
I
V
S
Y
T
G
S
N
C
S
H
Q
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q7YU24
810
91354
T734
L
K
M
I
V
D
L
T
S
A
N
C
S
H
Q
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q23424
774
87443
H693
M
Q
Q
V
S
T
A
H
T
H
H
C
E
T
Q
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
93.7
62.8
97.3
N.A.
94.9
95.3
N.A.
56.8
59.9
85.1
82.9
N.A.
43.5
N.A.
34.8
N.A.
Protein Similarity:
100
94
79.7
98.9
N.A.
98.8
98.5
N.A.
71.7
62.9
93
91.9
N.A.
64.8
N.A.
55.6
N.A.
P-Site Identity:
100
100
53.3
93.3
N.A.
93.3
93.3
N.A.
60
86.6
86.6
86.6
N.A.
46.6
N.A.
26.6
N.A.
P-Site Similarity:
100
100
86.6
100
N.A.
100
100
N.A.
93.3
100
100
100
N.A.
80
N.A.
46.6
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
9
0
0
25
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
100
0
0
0
% C
% Asp:
0
0
0
0
0
9
0
0
0
0
0
0
0
0
0
% D
% Glu:
0
0
0
0
0
0
0
0
0
0
0
0
9
0
0
% E
% Phe:
0
0
0
0
0
0
9
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
67
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
9
0
9
9
0
0
92
0
% H
% Ile:
0
0
0
75
42
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
17
0
0
0
0
0
0
0
0
0
0
0
0
0
% K
% Leu:
92
0
67
0
0
0
9
0
0
0
0
0
0
0
0
% L
% Met:
9
0
25
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
92
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
84
9
0
0
0
0
0
0
0
0
0
0
0
100
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% R
% Ser:
0
0
0
0
9
84
9
0
25
67
0
0
92
0
0
% S
% Thr:
0
0
0
0
0
9
0
92
9
0
0
0
0
9
0
% T
% Val:
0
0
0
25
50
0
0
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
67
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _